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Additional information Peer review information Nature Chemistry thanks Junjie Yao, Deju Ye and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

In addition, we selected a ligand-binding configuration that adopted a catalytically active pose, which placed the proton-donating C3 position of NADP near the nitrogen-adjacent tertiary carbon of R -THIQ

While these compounds show promise in preclinical studies, their safety and efficacy in humans remain to be established through proper clinical trials

Key examples include schisandrins (from Schisandra chinensis fruit), 7-hydroxymatairesinol (found in coniferous trees and in trace amounts in foods like strawberries and sesame), and sesame seed lignans such as sesamin, sesamol, and sesaminol (5557)

Notably, this study was conducted in Croatia, where selenium in the soil is very low