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Drugs approved to date have focused on glutamate excitotoxicity and oxidative stress, discussed in detail below

A positive correlation has also been demonstrated between high plasma testosterone concentration and fertility (300)

[30] [32] While many of these products are used as markers of oxidative stress, the products derived from linoleic acid appear far more predominant than arachidonic acid products and therefore easier to identify and quantify in, for example, atheromatous plaques

But "most" is not "all," and several specific populations may find genuine value in a sub-2.5 mg entry point

10.1371/journal.ppat.1000154 PLoS Pathog