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Studies show higher rates of B12 deficiency in people taking metformin at doses of 1,000 mg per day or more

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It works by blocking the proton pumps in the stomach lining that produce gastric acid

NAM transporters have also been investigated and recently identified as SLC29A1 and SLC29A2, which are also able to transport NR 73

In fact, the expression of those genes was lowered to levels similar to those of acne patients." So it looks like by intaking extra vitamin B12, we could be prompting the bacteria in our skin to slow down on their production of it, which leads to an imbalance that could heighten our risk of developing acne