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Only 3 of the voluntary wheel running (VWR) reported the range of distances run (Dibba et al., 2018[29]

Furthermore, CHAC1 negatively regulates the NOTCH1 receptor, a key player in determining cell fate, particularly in neuronal stem cells, affecting their development and differentiation ( 2.1 CHAC1 upregulation under arsenite stress and amino acid depletion As a stress-responsive protein, CHAC1 is critically involved in the cellular stress response

Foremost, Level 2 evidence, encompassing randomized controlled trials (RCTs) and systematic reviews with meta-analyses, offers the most robust validation