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Distribution of histologic subtypes in diagnosis

three studies, n = 718) compared to individuals without osteoarthritis

In the history of anticancer drug development, many landmark drugs (e.g., vincristine, paclitaxel, and artemisinin) were derived from natural products such as plants

In parallel, excessive Cu + generated in GSH-rich reductive environments can bind lipoylated mitochondrial TCA-cycle proteins such as DLAT, inducing aberrant protein aggregation and triggering cuproptosis across multiple cancer types 187,189,192-194

Correlation between TMB, MSI, and SAAM scores in STAD TMB has gained significant attention in cancer research and clinical practice as tumors with high TMB may be more susceptible to immune checkpoint inhibitor therapy 23