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2002b, Fariselli & al

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A higher consumption of vitamin-E-containing supplements decreased the airway hyperresponsiveness to ozone and other irritants in asthmatic [115] and healthy [116,117] subjects and increased the lung function in patients suffering from exercise-induced asthma [118]

It also serves as a crucial cofactor for non-redox NAD+-dependent enzymes, such as sirtuins and poly(ADP-ribose) polymerases (PARPs)

These changes included mucosal erosion, ulcerative lesions, deformation and distortion of colonic recesses, extensive infiltration of inflammatory cells (primarily lymphocytes and neutrophils) in the mucosa and submucosa, and depletion of goblet cells