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SAM levels were decreased, but S-adenosylhomocysteine (AdoHcy, SAH) levels were elevated considerably, with global DNA hypomethylation observed in both heterozygotes and homozygotes 38

PMID 22787590

Thus, due to the nature of the original diagnostic criteria for GHD, and the reticence to consider aging a disease per se, even though disease risk, incidence and severity can be attributed at least in part to declining activity of the GH neuroendcrine axis, the criteria for determining if secretagogue therapy is indicated as an intervention in aging, are less stringent than those promulgated by Endocrine Society guidelines

This paper presents gene profiling data relevant to GHKs effects on stem cells function

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