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The PPAR agonists rosiglitazone and pioglitazone were recently found to reduce the levels of 2-HG and H3K4me3 in the colon of mice with colitis and to regulate GSH and ROS levels in lamina propria lymphocytes by modulating GLS1/2-HG/H3K4me3 signaling in mouse models of colitis and asthma ( Table 1 )

Among all hormetic contexts, dietary hormesis stands out as the safest and most convenient form of hormesis that can be seamlessly integrated into daily life

The processes were performed in triplicate to ensure accurate results

doi: 10.1007/s12035-025-04772-1

LNP-mediated delivery of CRISPR RNP for wide-spread in vivo genome editing in mouse cornea