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But I'm sure you still have clients to this day who are resistant to it

EULAR points to consider for the definition of clinical and imaging features suspicious for progression from psoriasis to psoriatic arthritis

Mol Psychiatry 23 , 247256 (2018)

Current clinical guidelines for hyperuricemia and gout emphasize a dual approach: (1) acute flare management using nonsteroidal anti-inflammatory drugs (NSAIDs), colchicine, or corticosteroids and (2) long-term urate-lowering therapy (ULT) with xanthine oxidase inhibitors (e.g., allopurinol and febuxostat) or uricosurics (e.g., probenecid) (Karantas et al., 2024

UK product licences include specific cautions regarding use in severe gastrointestinal disease, making specialist assessment essential before considering these treatments