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study demonstrated that ipamorelin: Released GH in a dose-dependent manner Did not significantly elevate cortisol levels, even at high doses Did not significantly elevate prolactin levels Did not significantly affect ACTH, FSH, LH, or TSH (4) This selectivity gives ipamorelin a notably clean side-effect profile compared to other GH secretagogues

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None of the three compounds have human safety data in pregnancy or breastfeeding, and they are not FDA-approved

Tesamorelin (a component of the stack) Tesamorelin + Ipamorelin) is the only individual component with FDA approval, but only for its specific indication (HIV lipodystrophy, as monotherapy)