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Moreover, in Parkin deficient rodent models, no significant behavioral deficits were observed at either early or later ages (Dave et al., 2.1.3 Movement initiation test (stepping test) Deficits in forepaw movements have been shown to effectively model parkinsonian akinesia, and the type of test commonly used to examine this phenomenon is referred to as the stepping test

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MDR can occur both due to alteration of MDR1 gene expression and to increase in the dose of a gene--amplification of a fragment of the genome containing the MDR1 gene and five or six genes linked to it [17]

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1988, 4.Downey D., Larrabee W

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