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Lipid peroxidation up-regulates BACE1 expression in vivo : a possible early event of amyloidogenesis in Alzheimer's disease

1d, right panel) and in intact cells (Supplementary Fig

p53 also transcriptionally induces SAT1 (Spermidine/spermine N1-acetyltransferase 1) to elevate ALOX15 levels, leading to lipid peroxidation and ferroptosis [85,86]

Additionally, a more detailed analysis of iron supplementation, including the route, dose, and duration of administration, may also be informative but was not feasible with the available sample size