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Brain and serum from Cre-Swell1 mice had lower levels of pro-inflammatory factors IL-1, IL-6, macrophage inflammatory protein (MIP) 1, TNF-, and IFN- and increased levels of anti-inflammatory, IL-4 and IL-10, as compared to control animals (Chen et al., 2023)

A reduction of nitric oxide generation lowers the risk of damage to the S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), reduces ROS generation, and increases cell existence (Muronetz et al., 2017)

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Decreased Mobility Difficulty moving the joint through its full range of motion, leading to difficulty with basic movements such as walking, bending, or standing