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Napolitano) selected the most relevant studies for design, sample size and level of evidence, according to their knowledge and experience

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The five most upregulated genes in astrocytes were HMGB1, HSPH1, PTGES3, SLC7A11 and HSPA4L, while the five most downregulated genes were ANGPTL4, ETNPPL, SLC4A4, SLC6A11 and LINC00499 (Fig

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The latter derives from the cleavage of POMC by prohormone convertase-1 and acts via melanocortin-3 and -4 receptors (MC3R, MC4R) activation