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Often called the body's master antioxidant, glutathione plays a role in up to 90% of intracellular antioxidant activity

Sure enough, a popular sports medicine site confirms: Athletes with sickle cell trait are potentially more vulnerable to other serious conditions such as gross hematuria, splenic infarction, exertional heat stroke, severe muscle breakdown (rhabdomyolysis) and potentially even sudden death when participating in strenuous exercise under intense environmental conditions. Short of these devastating problems, which occur rarely with just the trait, more common symptoms may include muscle cramping/pain

The Institutional Review Board (IRB) and Independent Ethics Committee (IEC) approved the study and the informed consent form (CAAE: 42972521.9.0000.9287)

Free GSH neutralizes ROS via a REDOX reaction in which glutathione peroxidase oxidizes free GSH into GSSG [11], thereby producing a stable oxygen species and water as a byproduct

Canadian Medical Association Journal , 61 (1), 1