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The most serious but rare complication is metformin-associated lactic acidosis (MALA), typically occurring in the setting of renal impairment and mechanistically linked to mitochondrial complex I inhibition (Zhou et al., 2001)

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Combination Therapies : Combining Cellular Therapy and Stem Cells for Graves disease with other treatment modalities, such as antithyroid medications or immunomodulatory agents, may synergistically enhance therapeutic efficacy

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Consequently, the changes observed in the experimental animals, which were absent in the control group, can be attributed to high-altitude-induced hypoxia