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What they found: Dose-dependent stimulation of type II collagen (up to 2.5 baseline at 100 nM) Stimulation of aggrecan (up to 1.8 baseline) Inhibition of MMP-13 by ~40 % Partial protection against IL-1-induced matrix degradation Why it matters: It opened a completely new research area for AOD-9604 beyond lipolysis

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Because these are intramuscular injections, some patients may experience mild and temporary side effects at the injection site, including: Soreness or tenderness Mild redness or swelling Minor bruising These symptoms are typically minimal and resolve quickly

, inflammation, autoimmunity andrelevant to this reviewresponsiveness to antibody therapy) (108)

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