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These residues were selected because the hydrophobic side chain of I574 inserts into a relatively deep and narrow pocket of BRD4 ET , and the guanidino moiety of R573 is restrained through the contact with the carboxyl group of E653 of BRD4 ET

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Some commenters suggested that diagnostic radiopharmaceuticals that currently report ASP, or have been paid based on ASP while on pass-through status, continue to receive ASP-based payment post pass-through status expiration