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Due to the lack of side chains, glycine can exist in multiple three-dimensional conformations, which allows it to enter areas of the protein structure that other amino acids cannot, such as tight helical structures

Immunol Rev (2015) 268(1):13959

Notably, altretamine, an FDA-approved anti-neoplastic drug that was applied in ovarian cancer treatment, enhances ferroptosis by inhibiting GPX4 [230]