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By decreasing collagen, -SMA, and TIMP-1 expression, as well as by lowering SMAD2/3 phosphorylation and altering PI3K/Akt/FoxO1 signaling, EGCG prevents HSC activation in fibrosis (2529)

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of the preamble of this proposed rule, based on the most recent data available, our estimate of 75 percent of the amount that would otherwise have been paid as Medicare DSH payments (under the methodology outlined in section 1886(r)(2) of the Act) is adjusted to 65.71 percent of that amount to reflect the change in the percentage of individuals who are uninsured