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serine hydroxymethyltransferase (SHMT) transfers a one-carbon unit to THF, forming 5,10-methylene-THF

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SVCT1 has consistently been found to have a higher capacity to transport ascorbate (i.e., higher V m ), whereas SVCT2 has a slightly higher affinity for ascorbate, with a K 0.5 of 1070 M versus 20100 M for SVCT1

This necessitates studying the intricate interactions between hormetins and other food components, as well as their bioavailability and bioactivity within the body

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