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from pig stomachs

coli bacteria are a normal component of the gut microbiota, certain strains can grow rapidly in inflammatory environments and produce alpha-hemolysin, a toxin that may cause inflammation, bleeding, and leaky gut [7, 31]

Animal studies provide whole-body responses but are less amenable to mechanistic dissection and suffer from inter-species variability

Finally, it was recently demonstrated that HO-1 is required for an effective DNA damage response (DDR) and protection from senescence in multiple cells types including macrophages (74), further establishing the role of HO-1 in maintaining tissue homeostasis

The three branches are ligated onto a central maleimide moiety in a reaction sequence that exploits various click chemistries