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Based on available evidence, it may be cautiously hypothesized that cognitive resiliencethe capacity to maintain cognitive performance despite pathologyis reduced in schizophrenia due to pre-existing cognitive deficits, while resistance, defined as lower-than-expected neuropathological burden, remains unclear and requires biomarker-based investigation (213)

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Tedeschi PM, Markert EK, Gounder M, Lin H, Dvorzhinski D, Dolfi S, et al

Metformin also prevented fibrosis and restored glucose uptake in fat after insulin stimulation, although it did not prevent side effects of doxorubicin that included tissue loss and inflammatory response (140)