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2017;49:e291

Traditional therapy, centered on renin-angiotensin system blockers, can delay disease progression but fails to reverse renal fibrosis

doi: 10.1016/j.jcmgh.2021.04.014 138 RooksMGGarrettWS

This "paradoxical response" (where treatment temporarily makes symptoms worse) includes: Numbness and tingling Shooting pains Joint pain Increased sensitivity Temporary inflammation (swelling and irritation) While these symptoms generally indicate that treatment is working (as nerves begin to repair themselves), they can be distressing for patients and may require additional treatment for comfort

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