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Initial enthusiasm that such mutations accounted for all or most classical EDS has been restrained by subsequent findings, which suggest that 3050% of classical cases are caused by COL5A1 mutations and a substantially smaller number by COL5A2 mutations

376,380 The therapeutic effects of PF1801 are primarily achieved by modulating several key proteins that play central roles in inflammation and cellular metabolism

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Injection site reactions , including redness, itching, or swelling, occur in approximately 23% of patients

These time points were chosen to provide a comprehensive view of the hair regrowth process over the course of treatment