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Statistical significance was analyzed after normality testing using one-way ANOVA test followed by Bonferroni posttest (OriginPro 9.0.0, USA) to compare results each other at significance level p = 0.05

By contrast, the AdV vector formulation generates AdV-specific immunity, which can limit efficacy of repeated boosters owing to immune-mediated clearance of the vector

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Methods: We developed an agent-based state transition model with 16 histologically defined health states including no steatosis, metabolic dysfunction-associated steatotic liver (MASL) or F0, MASH, fibrosis F1-F3 with or without MASH, cirrhosis (F4), decompensated cirrhosis, liver cancer, transplant, and liver-related and other-cause death