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Large doses of Vitamin C have resulted in hemodialysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. The body further stated that glutathione affects melanin production, highlighting the long-term risk of skin cancer

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FIGURE 1 Cystine/Glutamate Antiporter Pathway System Xc(-) performs an important antioxidant function in the cell

According to Allen and Tresini (12), almost half of the ROS effects reported involve members of the mitogen-activated protein kinase (MAP kinase) and nuclear factor -B (NF B) pathways, but effects are not limited to these processes

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