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Their implication in CIPN through the overload of Ca 2+ entry has been demonstrated (Hill and Oliver, 2007

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A novel CPT1A covalent inhibitor modulates fatty acid oxidation and CPT1A-VDAC1 axis with therapeutic potential for colorectal cancer

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However, the tests employing both 14 Carbon or 13 Carbon labeled cobalamin require more validation to diagnose B12 malabsorption in clinical patients (Miller & Green, 2020)