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In Caco-2 cells (a human colorectal adenocarcinoma cell line that is widely used as a model for the intestinal epithelial barrier), the loss of SLC39A14 significantly reduced Mn secretion (defined as Mn transport from the outside of the base to the top) and strongly increased the absorption of Mn (defined as Mn transport from the top to the outside of the base), suggesting that SLC39A14 is the principal transporter that mediates basolateral Mn uptake in intestinal cells 66

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doi: 10.1186/2040-2392-4-42 [DOI] [PMC free article] [PubMed] [Google Scholar] 206.Tan TG, Sefik E, Geva-Zatorsky N, Kua L, Naskar D, Teng F, et al