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On the other hand, it also enables long distance distribution of synthetized BDNF across synaptically connected neuronal circuits and surrounding astrocytes after transcytosis of BDNF, a mechanism which was previously described or postulated for different neurotrophic factors (Bartheld and Johnson 2001

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20 , 21 Thus, in subsequent order, generalization from stomach epithelia to other epithelia appears, i.e., skin, liver, pancreas, heart, etc., and thereby, the wound-healing concept (providing that the stomach ulcer is much like the skin ulcer a wound that from the unknown reason fail to heal), leading to the axiomatic statement the healing is always the same. 30 Less emphasized, but essentially important is the final point in the original cytoprotection concept, the continuous presentation of the cytoprotective agent in gastric mucosa, and likely in the gastric juice, and thereby, permanently maintaining stomach mucosa integrity

The main risk is irritation