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From a therapeutic perspective, the central role of GPX4 is not equivalent to the only critical node

The brain is particularly susceptible to oxidative stress given its limited antioxidant enzymatic capacity to counteract reactive oxygen species production (Fisher-Wellman and Bloomer, 2009), habitual RT has been associated with a reduction in markers of oxidative stress at rest, with the bulk of evidence coming from animal models

We also observed that the binding of the E protein with TMED10 does not inhibit but rather enhances the association between TMED10 and IL1 (Supplementary Fig

Assembly of the MAC is terminated by vitronectin, clusterin, and FHR-1, respectively

5.2.3 Bottlenecks and opportunities in clinical translation While ferroptosis-targeted strategies show promise in OA models, the translation to clinical settings remains hindered by key limitations in safety, efficacy, and delivery