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doi: 10.3389/fimmu.2021.579140 280

Unlike autophagy or apoptosis, ferroptosis is specifically triggered by dysregulated lipid metabolism and impaired antioxidant defense, not by activation of established pathways like caspase

Metformin affects macrophages phenotype and improves the activity of glutathione peroxidase, superoxide dismutase, catalase and decreases malondialdehyde concentration in a partially AMPK-independent manner in LPS-stimulated human monocytes/macrophages

John Lorenzo Willis was Bishop and leader of this project

The method of administration involves reconstituting the solution with saline and administering it via slow intravenous route, following strict protocols to ensure safety and efficacy