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Moreover, the maintenance or increase in skeletal muscle glutamine concentration might be fundamental for muscle protein synthesis [127,128,129], to prevent muscle atrophy [38, 130] and to increase glycogen synthesis [131], particularly under catabolic conditions

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Likewise, IGF2 gene defects or imprinting defects cause severe fetal growth failure but somewhat less adverse effects on postnatal growth, more variable effects on brain development, and an absence of marked metabolic effects

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Though targeting the Nrf2 activity in the malignant cells can be considered as an ideal strategy to overcome cancer growth, an ideal inhibitor should not only be specific with potent efficacy but also have good bioavailability, bioactivity, and less toxicity