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14 A recent study by Suzuki et al

Key gaps include lack of longitudinal human datasets, validated phenotype biomarkers, optimal timing/duration of interventions, and pediatric safety/riskbenefit evidence, including uncertainty about applying adult antifibrotic drugs in children

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ALT and AST are indicators of hepatocyte injury, TBIL reflects bile metabolism and excretion, while ALB indicates the livers synthetic capacity [11]

A randomized, double-blind, placebo-controlled, delayed start study to assess rasagiline as a disease modifying therapy in Parkinson''s disease (the ADAGIO study): rationale, design, and baseline characteristics