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148:157357 10.1016/j.phymed.2025.157357 Excessive glutathione intake contributes to chemotherapy resistance in breast cancer: a propensity score matching analysis Cite Zhang Z, Gao J, Jia L, Kong S, Zhai M, Wang S, et al

This transporter localizes to the trans-Golgi network or late endosomes under basal conditions, but it relocalizes in a copper-dependent manner to a subapical, vesicular compartment, which facilitates both copper incorporation into ceruloplasmin and biliary copper excretion via lysosomes.180 Apart from copper, Long-Evans Cinnamon rats also have abnormal hepatic accumulation of iron.181 Chronic copper/iron accumulation in these rats leads to a 50% increase in lipid peroxidation, presumably due to copper/iron capability to induce oxidative stress by generating ROS via both mitochondrial dysfunction182 and Fenton-type, copper/iron-catalyzed Haber-Weiss reaction.183,184 These mutant rats exhibit a reduced basal bile salt-biliary excretion compared with normal, Long-Evans Agouti rats

Cell Calcium 49, 296305

In skeletal muscles of these animals, Akt/mTOR/p70 S6K signaling is decreased and MAFbx/Atrogin-1 is increased [76,172], and transgenic overexpression of IGF-1 inhibited muscle atrophy [167]

Transcriptional Convergence of Oligodendrocyte Lineage Progenitors During Development. Developmental Cell 46: 504517.e507