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Autophagy, a lysosome-dependent degradation process, includes macroautophagy, microautophagy and chaperone-mediated autophagy, playing dual roles in cell survival and death (43)

It often involves persistent worry, fear, or tension, even when theres no immediate threat

The combination synergistically inhibited cell proliferation and induced apoptosis more effectively than the individual agents, with mechanistic analysis revealing the inactivation of the EGFR/AKT/mTOR pathway, an increase in p53 levels, and enhanced mitochondrial dysfunction, offering a promising treatment strategy for p53 wild-type NSCLC patients

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