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10.1016/j.idairyj.2006.06.015 14

Concerning the metal-chelating ability, both DHLA and ALA, due to the presence of nearby sulfur atoms and a carboxyl group, are capable of chelating redox-active metals

After that, Nrf2 enters the nucleus, attaches itself to antioxidant response elements (AREs) found in the downstream target genes 5-flanking promoter/enhancer region, and starts the transcription of those genes