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These medications can cause a restless sensation called akathisia in a small percentage of patients, which is why diphenhydramine is often given alongside them as a preventive measure

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Am J Clin Nutr 88 : 333339 Witko-Sarsat V, Friedlander M, Capeillere-Blandin C, Nguyen-Khoa T, Nguyen AT, Zingraff J, Jungers P, Descamps-Latscha B 1996 Advanced oxidation protein products as a novel marker of oxidative stress in uremia

Overall, insulin resistance involves complex signalling rearrangements, with both defective and emergent signalling events potentially mediating impaired GLUT4 translocation (Figure 2)

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