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Additionally, it was shown that benfotiamine prevented ultrasound-induced aggression in a mouse model, while also ameliorating changes in glutamate subunit A1 and A2 and decreasing oxidative stress [76]

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Boutas I, Kontogeorgi A, Dimitrakakis C, Kalantaridou SN

However, these antineoplastic agents are able to cross the blood-nerve barrier and bind to the -tubulin (the building block of cytoskeleton in neuronal cells) of the peripheral sensory neurons and sensory nerve fibers (Windebank and Grisold, 2008)