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2012;21(3):380-5 Sun Z, Yin S, Zhao C, Fan LH, Hu H

3.3 Targeting VEGF-mediated tumor angiogenesis Vascular endothelial growth factor (VEGF) drives tumor angiogenesis through hypoxia-inducible factor 1 (HIF-1)-mediated transcriptional regulation, a process amplified by oncogene signals, growth factors, and hypoxic stress