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Studies show that around 68% of people who underwent a bariatric surgery such as gastric bypass reported a vitamin B12 deficiency

Metabolic modulators such as antioxidants, metformin, and melatonin also show potential by modulating mitochondrial and immune pathways

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Multivariate Cox regression analysis revealed that ln(Age), modified UICC stage, beyond Milan criteria, and ALBI grade 2 were independently significant factors associated with EHM in preoperative variables