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[18] Histamine stimulates the ovaries to make more estrogen, which can then lead to a vicious cycle where estrogen and histamine perpetuate one another

The precise mechanism may involve multiple processes including compensatory receptor crosstalk and it is to be further investigated

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That is, if the man fulfills the criteria established by the definition of IC/BPS (i.e., urinary frequency, painful urgency and/or painful bladder filling), he can be assumed to have the disorder

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