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Here, dasatinib was conjugated through an ester coupling to the carboxylic-acid arm of MHI-148 ( Figure 6 , C5 )

However, the impact of miRNAs on the development of resistance to both ADT and chemotherapy is much broader and involves a variety of targets and mechanisms [108, 110]

An observational study comparing permanent residents of La Rinconada (5100 m) and Puno (3800 m), both in Peru, revealed significant pathological changes in individuals living at the highest altitude

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