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In the same study, higher spermidine levels were associated with good water maze performances and decreased anxiety, whereas spermine had the opposite effect, suggesting differential roles for spermidine and spermine in behavioural outcome

These compounds help protect cells from oxidative stress, which can accumulate during intense training

Experimental studies have shown that inhibition of miR-34a in mice fed an HFD increases PPAR expression and AMPK activation, which promotes fatty acid -oxidation and reduces TG accumulation in the liver [300]

Because of these benefits, glutathione has become popular as a supplement, especially in the realm of skin brightening and anti-aging

Curr Hypertens Rev 2015