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531 Similarly to IL-1Ra, tocilizumab, an IL-6R antibody, has demonstrated efficacy in the treatment of systemic juvenile idiopathic arthritis (sJIA), severe rheumatoid arthritis, multicentric Castlemans disease, and CART therapy-induced CRS

DNA mutations are induced by reactive oxygen species, which cause abnormal cell proliferation that induces tumor growth

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There is also evidence that protein S -glutathionylation happens during grain development processes in which oxidative conditions prevail [237]

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