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It can also reverse the negative effects caused by BRIP1 downregulation, leading to a decrease in MDA levels and intracellular Fe 2+ content and an increase in GSH, Gpx4, and SLC7A11 levels ( 2+ and MDA levels, and reduced M2-type macrophage infiltration, whereas Fer-1 reversed these conditions ( Ferroptosis inducer 56 (FIN56) is a ferroptosis inducer that inhibits the activity of GPX4, thus leading to the accumulation of lipid peroxides within cells and thereby inducing ferroptosis