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In ferroptotic cells, the nuclear structure is intact, and there is no chromatin condensation and rupture, nuclear pyknosis rupture, nucleolus disappearance or apoptotic body formation, which are characteristic features of apoptosis (Liang et al., 2019)

Additionally, the references of the selected articles were reviewed, and relevant articles were further searched

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5-Amino-1MQ is still in an experimental stage

Their study revealed that hepatocyte glucose output decreased by 50% with NNMT knockdown, while NNMT overexpression increased it by 1.4-fold