hypothesis glutathione persister cells Drug-tolerant cancer are vulnerable to GPX4 inhibition JCI - CD8+ T cells
JCI CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione GPX4 Low GPX4 drives a sustained drug tolerant persister state in TNBC by a targetable adaptive FSP1 upregulation ScienceDirect JCI Insight Mitochondrial metabolic rewiring sensitizes mTORC1 inhibitor persister cells to cuproptosis hypothesis glutathione persister cells Identification and genetic dissection of convergent cell states Role of Glutathione in Cancer: Vaccinia related kinase 2 inhibition elicits vulnerability of glutathione metabolism in pancreatic cancer Cell Death & Disease
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