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Each workout produces an acute burst of reactive oxygen species (ROS) in muscle, which paradoxically triggers the cell's defense mechanisms a phenomenon known as mitohormesis ( 3.3 Physical capacity and metabolic health The systemic benefits of exercise in older adults extend to muscle strength, endurance, and metabolism

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Cyclooxygenase (COX) pathway (Figure 1) Two cyclooxygenase isozymes (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandins, thromboxanes, and prostacyclin, which are mediators of inflammation, fever, and pain