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Sources: Dixson et al

Moreover, ROS-dependent angiogenesis can be induced through the activation of this pathway to lead to the expression of HIF1 and VEGF [45]

Identification of novel risk and prognostic biomarkers may enable an individualized treatment pathway for patients with DPN from a potentially disease-modifying perspective, and provide onward opportunities for novel treatments that would be efficacious in early stages of DPN, and alter the natural course of the disease